Loss of Fibroblast-Dependent Androgen Receptor Activation in Prostate Cancer Cells is Involved in the Mechanism of Acquired Resistance to Castration

Loss of androgen receptor (AR) dependency in prostate cancer (PCa) cells is associated with progression to castration-resistant prostate cancer (CRPC). The tumor stroma is enriched in fibroblasts that secrete AR-activating factors. To investigate the roles of fibroblasts in AR activation under andro...

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Detalles Bibliográficos
Autores principales: Ishii, Kenichiro, Matsuoka, Izumi, Sasaki, Takeshi, Nishikawa, Kohei, Kanda, Hideki, Imai, Hiroshi, Hirokawa, Yoshifumi, Iguchi, Kazuhiro, Arima, Kiminobu, Sugimura, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780155/
https://www.ncbi.nlm.nih.gov/pubmed/31484364
http://dx.doi.org/10.3390/jcm8091379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780155/
https://www.ncbi.nlm.nih.gov/pubmed/31484364
http://dx.doi.org/10.3390/jcm8091379

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