Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans

Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology characterized by immune-mediated damage of synovial joints and antibodies to citrullinated antigens. Periodontal disease, a bacterial-induced inflammatory disease of the periodontium, is commonly observed in RA and has implicated...

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Autores principales: Gómez-Bañuelos, Eduardo, Mukherjee, Amarshi, Darrah, Erika, Andrade, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780899/
https://www.ncbi.nlm.nih.gov/pubmed/31454946
http://dx.doi.org/10.3390/jcm8091309
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author Gómez-Bañuelos, Eduardo
Mukherjee, Amarshi
Darrah, Erika
Andrade, Felipe
author_facet Gómez-Bañuelos, Eduardo
Mukherjee, Amarshi
Darrah, Erika
Andrade, Felipe
author_sort Gómez-Bañuelos, Eduardo
collection PubMed
description Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology characterized by immune-mediated damage of synovial joints and antibodies to citrullinated antigens. Periodontal disease, a bacterial-induced inflammatory disease of the periodontium, is commonly observed in RA and has implicated periodontal pathogens as potential triggers of the disease. In particular, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans have gained interest as microbial candidates involved in RA pathogenesis by inducing the production of citrullinated antigens. Here, we will discuss the clinical and mechanistic evidence surrounding the role of these periodontal bacteria in RA pathogenesis, which highlights a key area for the treatment and preventive interventions in RA.
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spelling pubmed-67808992019-10-30 Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans Gómez-Bañuelos, Eduardo Mukherjee, Amarshi Darrah, Erika Andrade, Felipe J Clin Med Review Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology characterized by immune-mediated damage of synovial joints and antibodies to citrullinated antigens. Periodontal disease, a bacterial-induced inflammatory disease of the periodontium, is commonly observed in RA and has implicated periodontal pathogens as potential triggers of the disease. In particular, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans have gained interest as microbial candidates involved in RA pathogenesis by inducing the production of citrullinated antigens. Here, we will discuss the clinical and mechanistic evidence surrounding the role of these periodontal bacteria in RA pathogenesis, which highlights a key area for the treatment and preventive interventions in RA. MDPI 2019-08-26 /pmc/articles/PMC6780899/ /pubmed/31454946 http://dx.doi.org/10.3390/jcm8091309 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gómez-Bañuelos, Eduardo
Mukherjee, Amarshi
Darrah, Erika
Andrade, Felipe
Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans
title Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans
title_full Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans
title_fullStr Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans
title_full_unstemmed Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans
title_short Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans
title_sort rheumatoid arthritis-associated mechanisms of porphyromonas gingivalis and aggregatibacter actinomycetemcomitans
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780899/
https://www.ncbi.nlm.nih.gov/pubmed/31454946
http://dx.doi.org/10.3390/jcm8091309
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