Neutralizing antibodies against Mayaro virus require Fc effector functions for protective activity

Despite causing outbreaks of fever and arthritis in multiple countries, no countermeasures exist against Mayaro virus (MAYV), an emerging mosquito-transmitted alphavirus. We generated 18 neutralizing mAbs against MAYV, 11 of which had “elite” activity that inhibited infection with EC(50) values of &...

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Detalles Bibliográficos
Autores principales: Earnest, James T., Basore, Katherine, Roy, Vicky, Bailey, Adam L., Wang, David, Alter, Galit, Fremont, Daved H., Diamond, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781005/
https://www.ncbi.nlm.nih.gov/pubmed/31337735
http://dx.doi.org/10.1084/jem.20190736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781005/
https://www.ncbi.nlm.nih.gov/pubmed/31337735
http://dx.doi.org/10.1084/jem.20190736

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