Development of a Strategy for Linear-Selective Cu-Catalyzed Reductive Coupling of Ketones and Allenes for the Synthesis of Chiral γ-Hydroxyaldehyde Equivalents

[Image: see text] We report the development of a stereoselective method for the allylation of ketones utilizing N-substituted allyl equivalents generated from a chiral allenamide. By choice of the appropriate ligand for the Cu-catalyst, high linear selectivity can be obtained with good diastereocont...

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Detalles Bibliográficos
Autores principales: Klake, Raphael K., Gargaro, Samantha L., Gentry, Skyler L., Elele, Sharon O., Sieber, Joshua D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781103/
https://www.ncbi.nlm.nih.gov/pubmed/31532684
http://dx.doi.org/10.1021/acs.orglett.9b02973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781103/
https://www.ncbi.nlm.nih.gov/pubmed/31532684
http://dx.doi.org/10.1021/acs.orglett.9b02973

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