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Coronin 1A depletion restores the nuclear stability and viability of Aip1/Wdr1-deficient neutrophils

Actin dynamics is central for cells, and especially for the fast-moving leukocytes. The severing of actin filaments is mainly achieved by cofilin, assisted by Aip1/Wdr1 and coronins. We found that in Wdr1-deficient zebrafish embryos, neutrophils display F-actin cytoplasmic aggregates and a complete...

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Detalles Bibliográficos
Autores principales: Bowes, Charnese, Redd, Michael, Yousfi, Malika, Tauzin, Muriel, Murayama, Emi, Herbomel, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781450/
https://www.ncbi.nlm.nih.gov/pubmed/31471458
http://dx.doi.org/10.1083/jcb.201901024