Conformational restriction of a type II FMS inhibitor leading to discovery of 5-methyl-N-(2-aryl-1H-benzo[d]imidazo-5-yl)isoxazole-4-carboxamide analogues as selective FLT3 inhibitors

A series of 4-arylamido 5-methylisoxazole derivatives incorporating benzimidazole was designed and synthesised by conformational restriction of an in-house type II FMS inhibitor. Kinase profiling of one compound revealed interesting features, with increased inhibitory potency towards FLT3 and concom...

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Detalles Bibliográficos
Autores principales: Im, Daseul, Moon, Hyungwoo, Kim, Jingwoong, Oh, Youri, Jang, Miyoung, Hah, Jung-Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781469/
https://www.ncbi.nlm.nih.gov/pubmed/31571509
http://dx.doi.org/10.1080/14756366.2019.1671837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781469/
https://www.ncbi.nlm.nih.gov/pubmed/31571509
http://dx.doi.org/10.1080/14756366.2019.1671837

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