Alternative trafficking of Weibel‐Palade body proteins in CRISPR/Cas9‐engineered von Willebrand factor–deficient blood outgrowth endothelial cells

BACKGROUND: Synthesis of the hemostatic protein von Willebrand factor (VWF) drives formation of endothelial storage organelles called Weibel‐Palade bodies (WPBs). In the absence of VWF, angiogenic and inflammatory mediators that are costored in WPBs are subject to alternative trafficking routes. In...

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Detalles Bibliográficos
Autores principales: Schillemans, Maaike, Kat, Marije, Westeneng, Jurjen, Gangaev, Anastasia, Hofman, Menno, Nota, Benjamin, van Alphen, Floris P. J., de Boer, Martin, van den Biggelaar, Maartje, Margadant, Coert, Voorberg, Jan, Bierings, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles: Haemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782018/
https://www.ncbi.nlm.nih.gov/pubmed/31624792
http://dx.doi.org/10.1002/rth2.12242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782018/
https://www.ncbi.nlm.nih.gov/pubmed/31624792
http://dx.doi.org/10.1002/rth2.12242

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