Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons

Disrupted circadian rhythms is a prominent and early feature of neurodegenerative diseases including Huntington’s disease (HD). In HD patients and animal models, striatal and hypothalamic neurons expressing molecular circadian clocks are targets of mutant Huntingtin (mHtt) pathogenicity. Yet how mHt...

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Detalles Bibliográficos
Autores principales: Xu, Fangke, Kula-Eversole, Elzbieta, Iwanaszko, Marta, Lim, Chunghun, Allada, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782096/
https://www.ncbi.nlm.nih.gov/pubmed/31593562
http://dx.doi.org/10.1371/journal.pgen.1008356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782096/
https://www.ncbi.nlm.nih.gov/pubmed/31593562
http://dx.doi.org/10.1371/journal.pgen.1008356

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