Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction

The alarmone (p)ppGpp regulates diverse targets, yet its target specificity and evolution remain poorly understood. Here, we elucidate the mechanism by which basal (p)ppGpp inhibits the purine salvage enzyme HPRT by sharing a conserved motif with its substrate PRPP. Intriguingly, HPRT regulation by...

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Detalles Bibliográficos
Autores principales: Anderson, Brent W, Liu, Kuanqing, Wolak, Christine, Dubiel, Katarzyna, She, Fukang, Satyshur, Kenneth A, Keck, James L, Wang, Jue D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783271/
https://www.ncbi.nlm.nih.gov/pubmed/31552824
http://dx.doi.org/10.7554/eLife.47534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783271/
https://www.ncbi.nlm.nih.gov/pubmed/31552824
http://dx.doi.org/10.7554/eLife.47534

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