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Stereotyped transcriptomic transformation of somatosensory neurons in response to injury

In mice, spared nerve injury replicates symptoms of human neuropathic pain and induces upregulation of many genes in somatosensory neurons. Here we used single cell transcriptomics to probe the effects of partial infraorbital transection of the trigeminal nerve at the cellular level. Uninjured neuro...

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Detalles Bibliográficos
Autores principales: Nguyen, Minh Q, Le Pichon, Claire E, Ryba, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783272/
https://www.ncbi.nlm.nih.gov/pubmed/31592768
http://dx.doi.org/10.7554/eLife.49679