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Dissecting splicing decisions and cell-to-cell variability with designed sequence libraries
Most human genes are alternatively spliced, allowing for a large expansion of the proteome. The multitude of regulatory inputs to splicing limits the potential to infer general principles from investigating native sequences. Here, we create a rationally designed library of >32,000 splicing events...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783452/ https://www.ncbi.nlm.nih.gov/pubmed/31594945 http://dx.doi.org/10.1038/s41467-019-12642-3 |