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Nonlinear mixed-effects models for modeling in vitro drug response data to determine problematic cancer cell lines
Cancer cell lines (CCLs) have been widely used to study of cancer. Recent studies have called into question the reliability of data collected on CCLs. Hence, we set out to determine CCLs that tend to be overly sensitive or resistant to a majority of drugs utilizing a nonlinear mixed-effects (NLME) m...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783462/ https://www.ncbi.nlm.nih.gov/pubmed/31594982 http://dx.doi.org/10.1038/s41598-019-50936-0 |