Modulation of PTH1R signaling by an ECD binding antibody results in inhibition of β-arrestin 2 coupling

Parathyroid hormone receptor 1 (PTH1R) belongs to the secretin class of G protein coupled receptors (GPCRs) and natively binds parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP). Ligand binding to PTH1R involves binding to the large extracellular domain (ECD) and the orthoster...

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Detalles Bibliográficos
Autores principales: Sarkar, Kaushik, Joedicke, Lisa, Westwood, Marta, Burnley, Rebecca, Wright, Michael, McMillan, David, Byrne, Bernadette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783463/
https://www.ncbi.nlm.nih.gov/pubmed/31594997
http://dx.doi.org/10.1038/s41598-019-51016-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783463/
https://www.ncbi.nlm.nih.gov/pubmed/31594997
http://dx.doi.org/10.1038/s41598-019-51016-z

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