Phosphodiesterase-2 Inhibitor Bay 60-7550 Ameliorates Aβ-Induced Cognitive and Memory Impairment via Regulation of the HPA Axis

The dysfunction of the hypothalamus–pituitary–adrenal (HPA) axis is often seen in Alzheimer’s disease (AD) patients with cognitive deficits. Selective inhibition of phosphodiesterase (PDE) 4 and 5 has already proven to be effective in reducing beta-amyloid 1–42 (Aβ1–42)-mediated pathology by regulat...

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Detalles Bibliográficos
Autores principales: Ruan, Lina, Du, Kai, Tao, Mengjia, Shan, Chunyan, Ye, Ruixuan, Tang, Yali, Pan, Hanbo, Lv, Jinpeng, Zhang, Meixi, Pan, Jianchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783519/
https://www.ncbi.nlm.nih.gov/pubmed/31632240
http://dx.doi.org/10.3389/fncel.2019.00432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783519/
https://www.ncbi.nlm.nih.gov/pubmed/31632240
http://dx.doi.org/10.3389/fncel.2019.00432

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