Structural basis of the activation of type 1 insulin-like growth factor receptor

Type 1 insulin-like growth factor receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation, and can be activated by IGF1, IGF2, and insulin. Here, we report the cryo-EM structure of full-length IGF1R–IGF1 complex in the active state. This structure reveals that onl...

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Detalles Bibliográficos
Autores principales: Li, Jie, Choi, Eunhee, Yu, Hongtao, Bai, Xiao-chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783537/
https://www.ncbi.nlm.nih.gov/pubmed/31594955
http://dx.doi.org/10.1038/s41467-019-12564-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783537/
https://www.ncbi.nlm.nih.gov/pubmed/31594955
http://dx.doi.org/10.1038/s41467-019-12564-0

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