Hemophilia A and B mice, but not VWF(−/−)mice, display bone defects in congenital development and remodeling after injury

While joint damage is the primary co-morbidity of hemophilia, osteoporosis and osteopenia are also observed. Coagulation factor VIII deficient (FVIII(−/−)) mice develop an osteoporotic phenotype in the absence of induced hemarthrosis that is exacerbated two weeks after an induced joint injury. Here...

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Detalles Bibliográficos
Autores principales: Taves, Sarah, Sun, Junjiang, Livingston, Eric W., Chen, Xin, Amiaud, Jerome, Brion, Regis, Hannah, William B., Bateman, Ted A., Heymann, Dominique, Monahan, Paul E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783554/
https://www.ncbi.nlm.nih.gov/pubmed/31594977
http://dx.doi.org/10.1038/s41598-019-50787-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783554/
https://www.ncbi.nlm.nih.gov/pubmed/31594977
http://dx.doi.org/10.1038/s41598-019-50787-9

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