Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele

IL-7 is a key factor in T cell immunity and common variants at IL7R, encoding its receptor, are associated with autoimmune disease susceptibility. IL7R mRNA is induced in stimulated monocytes, yet a function for IL7R in monocyte biology remains unexplored. Here we characterize genetic regulation of...

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Detalles Bibliográficos
Autores principales: Al-Mossawi, Hussein, Yager, Nicole, Taylor, Chelsea A., Lau, Evelyn, Danielli, Sara, de Wit, Jelle, Gilchrist, James, Nassiri, Isar, Mahe, Elise A., Lee, Wanseon, Rizvi, Laila, Makino, Seiko, Cheeseman, Jane, Neville, Matt, Knight, Julian C., Bowness, Paul, Fairfax, Benjamin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783569/
https://www.ncbi.nlm.nih.gov/pubmed/31594933
http://dx.doi.org/10.1038/s41467-019-12393-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783569/
https://www.ncbi.nlm.nih.gov/pubmed/31594933
http://dx.doi.org/10.1038/s41467-019-12393-1

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