Cargando…

Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele

IL-7 is a key factor in T cell immunity and common variants at IL7R, encoding its receptor, are associated with autoimmune disease susceptibility. IL7R mRNA is induced in stimulated monocytes, yet a function for IL7R in monocyte biology remains unexplored. Here we characterize genetic regulation of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Mossawi, Hussein, Yager, Nicole, Taylor, Chelsea A., Lau, Evelyn, Danielli, Sara, de Wit, Jelle, Gilchrist, James, Nassiri, Isar, Mahe, Elise A., Lee, Wanseon, Rizvi, Laila, Makino, Seiko, Cheeseman, Jane, Neville, Matt, Knight, Julian C., Bowness, Paul, Fairfax, Benjamin P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783569/ https://www.ncbi.nlm.nih.gov/pubmed/31594933 http://dx.doi.org/10.1038/s41467-019-12393-1

Ejemplares similares

Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma
por: Fairfax, Benjamin P, et al.
Publicado: (2020)

Genomic mapping of the MHC transactivator CIITA using an integrated ChIP-seq and genetical genomics approach
por: Wong, Daniel, et al.
Publicado: (2014)

Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity
por: Gilchrist, James J., et al.
Publicado: (2022)

scQCEA: a framework for annotation and quality control report of single-cell RNA-sequencing data
por: Nassiri, Isar, et al.
Publicado: (2023)

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis
por: Al-Mossawi, M. H., et al.
Publicado: (2017)

GENETICS OF GENE EXPRESSION IN PRIMARY IMMUNE CELLS IDENTIFIES CELL-SPECIFIC MASTER REGULATORS AND ROLES OF HLA ALLELES
por: Fairfax, Benjamin P, et al.
Publicado: (2012)

EPISPOT: An epigenome-driven approach for detecting and interpreting hotspots in molecular QTL studies
por: Ruffieux, Hélène, et al.
Publicado: (2021)

Fine mapping genetic determinants of the highly variably expressed MHC gene ZFP57
por: Plant, Katharine, et al.
Publicado: (2014)

Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases
por: Hammitzsch, Ariane, et al.
Publicado: (2018)

Novel Therapeutic Targets in Axial Spondyloarthritis
por: Worth, Claudia, et al.
Publicado: (2018)

Progress in our understanding of the pathogenesis of ankylosing spondylitis
por: Simone, Davide, et al.
Publicado: (2018)

High resolution HLA haplotyping by imputation for a British population bioresource
por: Neville, Matt J., et al.
Publicado: (2017)

A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation
por: Javaid, Hira, et al.
Publicado: (2023)

Systematic exploration of cell morphological phenotypes associated with a transcriptomic query
por: Nassiri, Isar, et al.
Publicado: (2018)

Genomic modulators of gene expression in human neutrophils
por: Naranbhai, Vivek, et al.
Publicado: (2015)

Nonparametric Simulation of Signal Transduction Networks with Semi-Synchronized Update
por: Nassiri, Isar, et al.
Publicado: (2012)

Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates
por: Simone, Davide, et al.
Publicado: (2021)

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression
por: Vecellio, Matteo, et al.
Publicado: (2016)

Regulatory Crosstalk of Doxorubicin, Estradiol and TNFα Combined Treatment in Breast Cancer-derived Cell Lines
por: Nassiri, Isar, et al.
Publicado: (2019)

AltHapAlignR: improved accuracy of RNA-seq analyses through the use of alternative haplotypes
por: Lee, Wanseon, et al.
Publicado: (2018)

Checkpoint-blocker-induced autoimmunity is associated with favourable outcome in metastatic melanoma and distinct T-cell expression profiles
por: Ye, Weiyu, et al.
Publicado: (2021)

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis
por: Chen, Liye, et al.
Publicado: (2016)

Polymorphism of β-casein in the Creole goat of Guadeloupe: evidence for a null allele
por: Mahé, MF, et al.
Publicado: (1993)

Optimising psoriatic arthritis therapy with immunological methods to increase standard evaluation: the protocol of an open-label multicentre, parallel-group, two-arm randomised controlled study evaluation precision medicine approach in the treatment of psoriatic arthritis
por: Ooms, Alexander, et al.
Publicado: (2023)

Characterisation of the global transcriptional response to heat shock and the impact of individual genetic variation
por: Humburg, Peter, et al.
Publicado: (2016)

IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma
por: Taylor, Chelsea A., et al.
Publicado: (2022)

Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4(+) versus CD8(+) T cells
por: Kasela, Silva, et al.
Publicado: (2017)

Activation‐Induced Killer Cell Immunoglobulin‐like Receptor 3DL2 Binding to HLA–B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis
por: Ridley, Anna, et al.
Publicado: (2016)

α(S1)-Cn(D), another allele associated with a decreased synthesis rate at the caprine α(S1)-casein locus
por: Mahé, MF, et al.
Publicado: (1989)

Dynamics of Quantum Correlations in Open Systems
por: Isar, Aurelian
Publicado: (2023)

Allelic Variation and Selection in Effector Genes of Phytophthora infestans (Mont.) de Bary
por: Morales, Juan G., et al.
Publicado: (2020)

Systematic allelic analysis defines the interplay of key pathways in X chromosome inactivation
por: Nesterova, Tatyana B., et al.
Publicado: (2019)

Systems view of adipogenesis via novel omics-driven and tissue-specific activity scoring of network functional modules
por: Nassiri, Isar, et al.
Publicado: (2016)

Dynamics of Entropy Production Rate in Two Coupled Bosonic Modes Interacting with a Thermal Reservoir
por: Mihaescu, Tatiana, et al.
Publicado: (2022)

Improving Chest Monitoring through Magnetic Resonance Angiogram Image Contrast Enhancement
por: Arvinti, Beatrice, et al.
Publicado: (2023)

Cohort Profile: The Oxford Biobank
por: Karpe, Fredrik, et al.
Publicado: (2018)

Chemical profile of Tetraclinis articulata (Vahl) Masters, and Juglans regia L. and Olea europaea L. var. Sylvestris used against oral diseases: in vitro analysis between polyphenolic content and aqueous extraction optimization
por: Harouak, Hazim, et al.
Publicado: (2021)

Carpathian Summer School of Physics on Exotic nuclei and nuclear/particle astrophysics (IV): From nuclei to stars
por: Trache, Livius, et al.
Publicado: (2012)

Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis
por: Penkava, Frank, et al.
Publicado: (2020)

Gauguin /
por: Bowness, Alan
Publicado: (1991)

Cannot write session to /tmp/vufind_sessions/sess_ngm08tu5l18ioi96jdq88ra41d