Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl‐xL inhibition

Liver‐X‐receptor (LXR) agonists are known to bear anti‐tumor activity. However, their efficacy is limited and additional insights regarding the underlying mechanism are necessary. By performing transcriptome analysis coupled with global polar metabolite screening, we show that LXR agonists, LXR623 a...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Trang Thi Thu, Ishida, Chiaki Tsuge, Shang, Enyuan, Shu, Chang, Torrini, Consuelo, Zhang, Yiru, Bianchetti, Elena, Sanchez‐Quintero, Maria J, Kleiner, Giulio, Quinzii, Catarina M, Westhoff, Mike‐Andrew, Karpel‐Massler, Georg, Canoll, Peter, Siegelin, Markus D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783693/
https://www.ncbi.nlm.nih.gov/pubmed/31468706
http://dx.doi.org/10.15252/emmm.201910769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783693/
https://www.ncbi.nlm.nih.gov/pubmed/31468706
http://dx.doi.org/10.15252/emmm.201910769

Ejemplares similares