Forced Degradation Testing as Complementary Tool for Biosimilarity Assessment

Oxidation of monoclonal antibodies (mAbs) can impact their efficacy and may therefore represent critical quality attributes (CQA) that require evaluation. To complement classical CQA, bevacizumab and infliximab were subjected to oxidative stress by H(2)O(2) for 24, 48, or 72 h to probe their oxidati...

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Detalles Bibliográficos
Autores principales: Dyck, Yan Felix Karl, Rehm, Daniel, Joseph, Jan Felix, Winkler, Karsten, Sandig, Volker, Jabs, Wolfgang, Parr, Maria Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783961/
https://www.ncbi.nlm.nih.gov/pubmed/31330921
http://dx.doi.org/10.3390/bioengineering6030062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783961/
https://www.ncbi.nlm.nih.gov/pubmed/31330921
http://dx.doi.org/10.3390/bioengineering6030062

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