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Forced Degradation Testing as Complementary Tool for Biosimilarity Assessment
Oxidation of monoclonal antibodies (mAbs) can impact their efficacy and may therefore represent critical quality attributes (CQA) that require evaluation. To complement classical CQA, bevacizumab and infliximab were subjected to oxidative stress by H(2)O(2) for 24, 48, or 72 h to probe their oxidati...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783961/ https://www.ncbi.nlm.nih.gov/pubmed/31330921 http://dx.doi.org/10.3390/bioengineering6030062 |