Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates

Over the two last decades, venom toxins have been explored as alternatives to opioids to treat chronic debilitating pain. At present, approximately 20 potential analgesic toxins, mainly from spider venoms, are known to inhibit with high affinity the Na(V)1.7 subtype of voltage-gated sodium (Na(V)) c...

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Detalles Bibliográficos
Autores principales: Gonçalves, Tânia C., Lesport, Pierre, Kuylle, Sarah, Stura, Enrico, Ciolek, Justyna, Mourier, Gilles, Servent, Denis, Bourinet, Emmanuel, Benoit, Evelyne, Gilles, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784069/
https://www.ncbi.nlm.nih.gov/pubmed/31443554
http://dx.doi.org/10.3390/toxins11090484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784069/
https://www.ncbi.nlm.nih.gov/pubmed/31443554
http://dx.doi.org/10.3390/toxins11090484

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