Cargando…

Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates

Over the two last decades, venom toxins have been explored as alternatives to opioids to treat chronic debilitating pain. At present, approximately 20 potential analgesic toxins, mainly from spider venoms, are known to inhibit with high affinity the Na(V)1.7 subtype of voltage-gated sodium (Na(V)) c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gonçalves, Tânia C., Lesport, Pierre, Kuylle, Sarah, Stura, Enrico, Ciolek, Justyna, Mourier, Gilles, Servent, Denis, Bourinet, Emmanuel, Benoit, Evelyne, Gilles, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784069/ https://www.ncbi.nlm.nih.gov/pubmed/31443554 http://dx.doi.org/10.3390/toxins11090484

Ejemplares similares

The Na(V)1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia Neurons
por: Gonçalves, Tânia C., et al.
Publicado: (2018)

Corrigendum: The Na(V)1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia Neurons
por: Gonçalves, Tânia C., et al.
Publicado: (2018)

Phlogiellus bundokalbo spider venom: cytotoxic fractions against human lung adenocarcinoma (A549) cells
por: Mayor, Anna Beatriz R., et al.
Publicado: (2020)

Chemical Synthesis, Proper Folding, Na(v) Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1
por: Nicolas, Sébastien, et al.
Publicado: (2019)

Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins
por: Blanchet, Guillaume, et al.
Publicado: (2017)

Engineering of Three-Finger Fold Toxins Creates Ligands with Original Pharmacological Profiles for Muscarinic and Adrenergic Receptors
por: Fruchart-Gaillard, Carole, et al.
Publicado: (2012)

Copper mediated amyloid-β binding to Transthyretin
por: Ciccone, Lidia, et al.
Publicado: (2018)

Characterization of a Novel Conus bandanus Conopeptide Belonging to the M-Superfamily Containing Bromotryptophan
por: Nguyen, Bao, et al.
Publicado: (2014)

Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
por: Wu, Ting, et al.
Publicado: (2019)

New species of Southeast Asian Dwarf Tarantula from Thailand: Phlogiellus Pocock, 1897 (Theraphosidae, Selenocosmiinae)
por: Chomphuphuang, Narin, et al.
Publicado: (2017)

Engineered Synthetic STxB for Enhanced Cytosolic Delivery
por: Hadjerci, Justine, et al.
Publicado: (2023)

Synthetic Analogues of Huwentoxin-IV Spider Peptide With Altered Human Na(V)1.7/Na(V)1.6 Selectivity Ratios
por: Lopez, Ludivine, et al.
Publicado: (2021)

Neuroactive venom compounds obtained from Phlogiellus bundokalbo as potential leads for neurodegenerative diseases: insights on their acetylcholinesterase and beta-secretase inhibitory activities in vitro
por: Lopez, Simon Miguel M., et al.
Publicado: (2021)

Antinociceptive and Anti-Inflammatory Activity from Algae of the Genus Caulerpa
por: da Matta, Carolina Babosa Brito, et al.
Publicado: (2011)

Synthetic Pinnatoxins A and G Reversibly Block Mouse Skeletal Neuromuscular Transmission In Vivo and In Vitro
por: Benoit, Evelyne, et al.
Publicado: (2019)

The spider genus Pterotricha in Iran, with the description of a new genus (Araneae, Gnaphosidae)
por: Zamani, Alireza, et al.
Publicado: (2018)

On the spider genus Amaurobius (Araneae, Amaurobiidae) in India and Nepal
por: Marusik, Yuri M., et al.
Publicado: (2011)

Comparative venomic profiles of three spiders of the genus Phoneutria
por: Fernandes, Frederico Francisco, et al.
Publicado: (2022)

Antinociceptive and antitumor activity of novel synthetic mononuclear Ruthenium (II) compounds
por: Sunder A, Shyam, et al.
Publicado: (2013)

A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems
por: da Fonseca Pacheco, Daniela, et al.
Publicado: (2016)

Respiratory Effects of Sarafotoxins from the Venom of Different Atractaspis Genus Snake Species
por: Malaquin, Stéphanie, et al.
Publicado: (2016)

Orthologous genes identified by transcriptome sequencing in the spider genus Stegodyphus
por: Mattila, Tiina M, et al.
Publicado: (2012)

Revalidation of the spider genus Citharoceps Chamberlin, 1924 (Araneae, Segestriidae)
por: Giroti, André Marsola, et al.
Publicado: (2015)

Method for the Destruction of Endotoxin in Synthetic Spider Silk Proteins
por: Decker, Richard E., et al.
Publicado: (2018)

Verified envenomations by crevice weaver spiders (genus Kukulcania): Bites are of minor expression but the spiders are commonly misidentified as medically important brown recluses (genus Loxosceles) in North America
por: Vetter, Richard S.
Publicado: (2022)

Brown Spider (Loxosceles genus) Venom Toxins: Tools for Biological Purposes
por: Chaim, Olga Meiri, et al.
Publicado: (2011)

On the spider genus Arboricaria with the description of a new species (Araneae, Gnaphosidae)
por: Mikhailov, Kirill G.
Publicado: (2016)

A new genus of oonopid spiders from Myanmar (Araneae, Oonopidae)
por: Tong, Yanfeng, et al.
Publicado: (2018)

On three species of the spider genus Pimoa (Araneae, Pimoidae) from China
por: Zhang, Xiaoqing, et al.
Publicado: (2019)

Piezoresponse, Mechanical, and Electrical Characteristics of Synthetic Spider Silk Nanofibers
por: Shehata, Nader, et al.
Publicado: (2018)

The Antinociceptive and Anti-Inflammatory Activities of Caulerpin, a Bisindole Alkaloid Isolated from Seaweeds of the Genus Caulerpa
por: de Souza, Éverton Tenório, et al.
Publicado: (2009)

Taxonomic revision of the Trapdoor spider genus Eucteniza Ausserer (Araneae, Mygalomorphae, Euctenizidae)
por: Bond, Jason E., et al.
Publicado: (2013)

A revision of the Afrotropical spider genus Cambalida Simon, 1909 (Araneae, Corinnidae)
por: Haddad, Charles Richard
Publicado: (2012)

A genus-level taxonomic review of primitively segmented spiders (Mesothelae, Liphistiidae)
por: Xu, Xin, et al.
Publicado: (2015)

High endemism at cave entrances: a case study of spiders of the genus Uthina
por: Yao, Zhiyuan, et al.
Publicado: (2016)

A new genus of minute Sparianthinae spiders from the Caribbean (Araneae, Sparassidae)
por: Rheims, Cristina Anne, et al.
Publicado: (2018)

Three new species of the spider genus Asceua from Malaysia (Araneae, Zodariidae)
por: Zhang, Bao-Shi, et al.
Publicado: (2018)

Revision of the ant-eating spider genus Mallinus Simon, 1893 (Araneae, Zodariidae)
por: Haddad, Charles R., et al.
Publicado: (2019)

A taxonomic monograph of the liphistiid spider genus Heptathela, endemic to Japanese islands
por: Xu, Xin, et al.
Publicado: (2019)

A new genus of spider beetle (Coleoptera, Ptinidae) from western Peru
por: Philips, T. Keith, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_q7tki48kn4hh49tdijpr0fakes