Optimization of an Antibody Light Chain Framework Enhances Expression, Biophysical Properties and Pharmacokinetics

Efficacy, safety, and manufacturability of therapeutic antibodies are influenced by their biopharmaceutical and biophysical properties. These properties can be optimized by library approaches or rationale protein design. Here, we employed a protein engineering approach to modify the variable domain...

Descripción completa

Detalles Bibliográficos
Autores principales: Douillard, Patrice, Freissmuth, Michael, Antoine, Gerhard, Thiele, Michael, Fleischanderl, Daniel, Matthiessen, Peter, Voelkel, Dirk, Kerschbaumer, Randolf J., Scheiflinger, Friedrich, Sabarth, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784111/
https://www.ncbi.nlm.nih.gov/pubmed/31544852
http://dx.doi.org/10.3390/antib8030046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784111/
https://www.ncbi.nlm.nih.gov/pubmed/31544852
http://dx.doi.org/10.3390/antib8030046

Ejemplares similares