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Telmisartan increases hepatic glucose production via protein kinase C ζ-dependent insulin receptor substrate-1 phosphorylation in HepG2 cells and mouse liver

BACKGROUND: Dysregulation of hepatic glucose production (HGP) contributes to the development of type 2 diabetes mellitus. Telmisartan, an angiotensin II type 1 receptor blocker (ARB), has various ancillary effects in addition to common blood pressure-lowering effects. The effects and mechanism of te...

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Detalles Bibliográficos
Autores principales: Cho, Kae Won, Cho, Du-Hyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yeungnam University College of Medicine 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784617/
https://www.ncbi.nlm.nih.gov/pubmed/31620609
http://dx.doi.org/10.12701/yujm.2019.00059