SLC19A1 transports immunoreactive cyclic dinucleotides

The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage(1,2). Cytosolic DNA triggers immune responses by activating the cGAS/STING pathway(3). The binding of DNA to the cytosolic enzyme cGAMP synthase (cGAS), activates its...

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Detalles Bibliográficos
Autores principales: Luteijn, Rutger D., Zaver, Shivam A., Gowen, Benjamin G., Wyman, Stacia, Garelis, Nick, Onia, Liberty, McWhirter, Sarah M., Katibah, George E., Corn, Jacob E., Woodward, Joshua J., Raulet, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785039/
https://www.ncbi.nlm.nih.gov/pubmed/31511694
http://dx.doi.org/10.1038/s41586-019-1553-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785039/
https://www.ncbi.nlm.nih.gov/pubmed/31511694
http://dx.doi.org/10.1038/s41586-019-1553-0

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