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SLC19A1 transports immunoreactive cyclic dinucleotides
The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage(1,2). Cytosolic DNA triggers immune responses by activating the cGAS/STING pathway(3). The binding of DNA to the cytosolic enzyme cGAMP synthase (cGAS), activates its...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785039/ https://www.ncbi.nlm.nih.gov/pubmed/31511694 http://dx.doi.org/10.1038/s41586-019-1553-0 |