Bexarotene therapy ameliorates behavioral deficits and induces functional and molecular changes in very-old Triple Transgenic Mice model of Alzheimer´s disease

INTRODUCTION: Bexarotene, a retinoid X receptor agonist, improves cognition in murine models of Alzheimer’s disease (AD). This study evaluated the effects of bexarotene on pathological and electrophysiological changes in very old triple transgenic AD mice (3xTg-AD mice). METHODS: 24-month-old 3xTg-A...

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Detalles Bibliográficos
Autores principales: Muñoz-Cabrera, Jonathan Mauricio, Sandoval-Hernández, Adrián Gabriel, Niño, Andrea, Báez, Tatiana, Bustos-Rangel, Angie, Cardona-Gómez, Gloria Patricia, Múnera, Alejandro, Arboleda, Gonzalo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785083/
https://www.ncbi.nlm.nih.gov/pubmed/31596896
http://dx.doi.org/10.1371/journal.pone.0223578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785083/
https://www.ncbi.nlm.nih.gov/pubmed/31596896
http://dx.doi.org/10.1371/journal.pone.0223578

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