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Ubiquitin-proteasomal regulation of chromatin remodeler INO80 in the nucleus accumbens mediates persistent cocaine craving
Neuroadaptations in the nucleus accumbens (NAc) underlie cue-induced cocaine craving that intensifies (“incubates”) during abstinence and is believed to contribute to persistent relapse vulnerability. Changes in gene expression often govern perpetual behavioral abnormalities, but epigenetic plastici...
Autores principales: | Werner, C. T., Mitra, S., Martin, J. A., Stewart, A. F., Lepack, A. E., Ramakrishnan, A., Gobira, P. H., Wang, Z.-J., Neve, R. L., Gancarz, A. M., Shen, L., Maze, I., Dietz, D. M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785264/ https://www.ncbi.nlm.nih.gov/pubmed/31633032 http://dx.doi.org/10.1126/sciadv.aay0351 |
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