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BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis
BMP7/BMP2 or BMP7/BMP4 heterodimers are more active than homodimers in vitro, but it is not known whether these heterodimers signal in vivo. To test this, we generated knock in mice carrying a mutation (Bmp7(R-GFlag)) that prevents proteolytic activation of the dimerized BMP7 precursor protein. This...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785266/ https://www.ncbi.nlm.nih.gov/pubmed/31566563 http://dx.doi.org/10.7554/eLife.48872 |