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BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis

BMP7/BMP2 or BMP7/BMP4 heterodimers are more active than homodimers in vitro, but it is not known whether these heterodimers signal in vivo. To test this, we generated knock in mice carrying a mutation (Bmp7(R-GFlag)) that prevents proteolytic activation of the dimerized BMP7 precursor protein. This...

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Detalles Bibliográficos
Autores principales:	Kim, Hyung-Seok, Neugebauer, Judith, McKnite, Autumn, Tilak, Anup, Christian, Jan L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785266/ https://www.ncbi.nlm.nih.gov/pubmed/31566563 http://dx.doi.org/10.7554/eLife.48872

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