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Genome‐wide meta‐analysis of SNP and antihypertensive medication interactions on left ventricular traits in African Americans

BACKGROUND: Left ventricular (LV) hypertrophy affects up to 43% of African Americans (AAs). Antihypertensive treatment reduces LV mass (LVM). However, interindividual variation in LV traits in response to antihypertensive treatments exists. We hypothesized that genetic variants may modify the associ...

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Detalles Bibliográficos
Autores principales: Do, Anh N., Zhao, Wei, Baldridge, Abigail S., Raffield, Laura M., Wiggins, Kerri L., Shah, Sanjiv J., Aslibekyan, Stella, Tiwari, Hemant K., Limdi, Nita, Zhi, Degui, Sitlani, Colleen M., Taylor, Kent D., Psaty, Bruce M., Sotoodehnia, Nona, Brody, Jennifer A., Rasmussen‐Torvik, Laura J., Lloyd‐Jones, Donald, Lange, Leslie A., Wilson, James G., Smith, Jennifer A., Kardia, Sharon L. R., Mosley, Thomas H., Vasan, Ramachandran S., Arnett, Donna K., Irvin, Marguerite R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785453/
https://www.ncbi.nlm.nih.gov/pubmed/31407531
http://dx.doi.org/10.1002/mgg3.788