Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity

Many compounds that appear promising in preclinical species, fail in human clinical trials due to safety concerns. The FDA has strongly encouraged the application of modeling in drug development to improve product safety. This study illustrates how DILIsym, a computational representation of liver in...

Descripción completa

Detalles Bibliográficos
Autores principales: Generaux, Grant, Lakhani, Vinal V., Yang, Yuching, Nadanaciva, Sashi, Qiu, Luping, Riccardi, Keith, Di, Li, Howell, Brett A., Siler, Scott Q., Watkins, Paul B., Barton, Hugh A., Aleo, Michael D., Shoda, Lisl K. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785660/
https://www.ncbi.nlm.nih.gov/pubmed/31624633
http://dx.doi.org/10.1002/prp2.523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785660/
https://www.ncbi.nlm.nih.gov/pubmed/31624633
http://dx.doi.org/10.1002/prp2.523

Ejemplares similares