Binding and structural asymmetry governs ligand sensitivity in a cyclic nucleotide–gated ion channel

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels open more easily when cAMP or cGMP bind to a domain in the intracellular C-terminus in each of four identical subunits. How sensitivity of the channels to these ligands is determined is not well understood. Here, we apply a mathemati...

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Detalles Bibliográficos
Autores principales: Ng, Leo C.T., Zhuang, Meiying, Van Petegem, Filip, Li, Yue Xian, Accili, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785730/
https://www.ncbi.nlm.nih.gov/pubmed/31481514
http://dx.doi.org/10.1085/jgp.201812162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785730/
https://www.ncbi.nlm.nih.gov/pubmed/31481514
http://dx.doi.org/10.1085/jgp.201812162

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