Use of Terahertz-Raman Spectroscopy to Determine Solubility of the Crystalline Active Pharmaceutical Ingredient in Polymeric Matrices during Hot Melt Extrusion

[Image: see text] Polymer-based amorphous solid dispersions (ASDs) comprise one of the most promising formulation strategies devised to improve the oral bioavailability of poorly water-soluble drugs. Exploitation of such systems in marketed products has been limited because of poor understanding of...

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Detalles Bibliográficos
Autores principales: Bordos, Ecaterina, Islam, Muhammad T., Florence, Alastair J., Halbert, Gavin W., Robertson, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785800/
https://www.ncbi.nlm.nih.gov/pubmed/31436094
http://dx.doi.org/10.1021/acs.molpharmaceut.9b00703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785800/
https://www.ncbi.nlm.nih.gov/pubmed/31436094
http://dx.doi.org/10.1021/acs.molpharmaceut.9b00703

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