Identification of Cancer–associated metabolic vulnerabilities by modeling multi-objective optimality in metabolism

BACKGROUND: Cancer cells undergo global reprogramming of cellular metabolism to satisfy demands of energy and biomass during proliferation and metastasis. Computational modeling of genome-scale metabolic models is an effective approach for designing new therapeutics targeting dysregulated cancer met...

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Detalles Bibliográficos
Autores principales: Dai, Ziwei, Yang, Shiyu, Xu, Liyan, Hu, Hongrong, Liao, Kun, Wang, Jianghuang, Wang, Qian, Gao, Shuaishi, Li, Bo, Lai, Luhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785927/
https://www.ncbi.nlm.nih.gov/pubmed/31601242
http://dx.doi.org/10.1186/s12964-019-0439-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785927/
https://www.ncbi.nlm.nih.gov/pubmed/31601242
http://dx.doi.org/10.1186/s12964-019-0439-y

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