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Identification of Cancer–associated metabolic vulnerabilities by modeling multi-objective optimality in metabolism
BACKGROUND: Cancer cells undergo global reprogramming of cellular metabolism to satisfy demands of energy and biomass during proliferation and metastasis. Computational modeling of genome-scale metabolic models is an effective approach for designing new therapeutics targeting dysregulated cancer met...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785927/ https://www.ncbi.nlm.nih.gov/pubmed/31601242 http://dx.doi.org/10.1186/s12964-019-0439-y |