A conditional inducible JAK2(V617F) transgenic mouse model reveals myeloproliferative disease that is reversible upon switching off transgene expression

Aberrant activation of the JAK/STAT pathway is thought to be the critical event in the pathogenesis of the chronic myeloproliferative neoplasms, polycythemia vera, essential thrombocythemia and primary myelofibrosis. The most frequent genetic alteration in these pathologies is the activating JAK2(V6...

Descripción completa

Detalles Bibliográficos
Autores principales: Chapeau, Emilie A., Mandon, Emeline, Gill, Jason, Romanet, Vincent, Ebel, Nicolas, Powajbo, Violetta, Andraos-Rey, Rita, Qian, Zhiyan, Kininis, Miltos, Zumstein-Mecker, Sabine, Ito, Moriko, Hynes, Nancy E., Tiedt, Ralph, Hofmann, Francesco, Eshkind, Leonid, Bockamp, Ernesto, Kinzel, Bernd, Mueller, Matthias, Murakami, Masato, Baffert, Fabienne, Radimerski, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786561/
https://www.ncbi.nlm.nih.gov/pubmed/31600213
http://dx.doi.org/10.1371/journal.pone.0221635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786561/
https://www.ncbi.nlm.nih.gov/pubmed/31600213
http://dx.doi.org/10.1371/journal.pone.0221635

Ejemplares similares