Cargando…

Plasma mitochondrial DNA is elevated in obese type 2 diabetes mellitus patients and correlates positively with insulin resistance

Cells damaged by mechanical or infectious injury release proinflammatory mitochondrial DNA (mtDNA) fragments into the circulation. We evaluated the relation between plasma levels of mtDNA fragments in obese type 2 diabetes mellitus (T2DM) patients and measures of chronic inflammation and insulin res...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuzefovych, Larysa V., Pastukh, Viktor M., Ruchko, Mykhaylo V., Simmons, Jon D., Richards, William O., Rachek, Lyudmila I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786592/ https://www.ncbi.nlm.nih.gov/pubmed/31600210 http://dx.doi.org/10.1371/journal.pone.0222278

Ejemplares similares

Effect of Bariatric Surgery on Plasma Cell-Free Mitochondrial DNA, Insulin Sensitivity and Metabolic Changes in Obese Patients
por: Yuzefovych, Larysa V., et al.
Publicado: (2023)

Mitochondrial DNA Damage and Dysfunction, and Oxidative Stress Are Associated with Endoplasmic Reticulum Stress, Protein Degradation and Apoptosis in High Fat Diet-Induced Insulin Resistance Mice
por: Yuzefovych, Larysa V., et al.
Publicado: (2013)

Mitochondrial DNA Damage via Augmented Oxidative Stress Regulates Endoplasmic Reticulum Stress and Autophagy: Crosstalk, Links and Signaling
por: Yuzefovych, Larysa V., et al.
Publicado: (2013)

Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences
por: Pastukh, Viktor M, et al.
Publicado: (2011)

Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice
por: Hashizume, Masahiro, et al.
Publicado: (2014)

Novel attributes of cell‐free plasma mitochondrial DNA in traumatic injury
por: Daly, Grant T., et al.
Publicado: (2022)

Elevated Plasma SPARC Levels Are Associated with Insulin Resistance, Dyslipidemia, and Inflammation in Gestational Diabetes Mellitus
por: Xu, Lu, et al.
Publicado: (2013)

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance
por: Haus, Jacob M., et al.
Publicado: (2009)

A Non-obese, Treatment-Naive Japanese Diabetic Patient With Elevated Insulin Clearance and Hyperglycemia Under Enhanced Insulin Sensitivity and Increased Insulin Secretion: Elevated Insulin Clearance as Type 2 Japanese Diabetes Mellitus (T2JDM)
por: Sugiyama, Seigo, et al.
Publicado: (2021)

Elevated Serum TNF-α Is Related to Obesity in Type 2 Diabetes Mellitus and Is Associated with Glycemic Control and Insulin Resistance
por: Alzamil, Hana
Publicado: (2020)

Plasma Sphingosine-1-Phosphate Is Elevated in Obesity
por: Kowalski, Greg M., et al.
Publicado: (2013)

Association of obesity and insulin resistance to gestational diabetes mellitus
por: Thilak, Swathi, et al.
Publicado: (2023)

Acute PDE4 Inhibition Induces a Transient Increase in Blood Glucose in Mice
por: Irelan, Daniel, et al.
Publicado: (2023)

The Insulin-Like Growth Factor System in Obesity, Insulin Resistance and Type 2 Diabetes Mellitus
por: Lewitt, Moira S., et al.
Publicado: (2014)

Plasma Adiponectin and Insulin Resistance in Korean Type 2 Diabetes Mellitus
por: Kim, Mi-Jin, et al.
Publicado: (2005)

Complement activation in obesity, insulin resistance, and type 2 diabetes mellitus
por: Shim, Kyumin, et al.
Publicado: (2020)

Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation
por: Rabin-Court, Aviva, et al.
Publicado: (2019)

Gestational diabetes mellitus: Non-insulin management
por: Magon, Navneet, et al.
Publicado: (2011)

The Functionality of Minimal PiggyBac Transposons in Mammalian Cells
por: Troyanovsky, Boris, et al.
Publicado: (2016)

Plasma concentrations of zonulin are elevated in obese men with fatty liver disease
por: Kim, A-Sol, et al.
Publicado: (2018)

Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus
por: Bao, Wei, et al.
Publicado: (2010)

Platelets activation is associated with elevated plasma mitochondrial DNA during cardiopulmonary bypass
por: Qin, Chaoyi, et al.
Publicado: (2016)

Obesity as a risk factor for non-insulin-dependent diabetes mellitus in Korea.
por: Sung, E. J., et al.
Publicado: (2001)

Incidence of Insulin Resistance in Obese Adolescent of Type-2 Diabetes Mellitus Patients
por: Javaid, Farrukh, et al.
Publicado: (2021)

Mitochondrial Phenotype as a Driver of the Racial Dichotomy in Obesity and Insulin Resistance
por: Jevtovic, Filip, et al.
Publicado: (2022)

Elevated Serum Gamma-Glutamyltransferase Is a Strong Marker of Insulin Resistance in Obese Children
por: Lee, Seon Yeong, et al.
Publicado: (2013)

Preliminary evidence for obesity-associated insulin resistance in adolescents without elevations of inflammatory cytokines
por: Cohen, Jessica I, et al.
Publicado: (2012)

Insulin Resistance Is Associated with Intraocular Pressure Elevation in a Non-Obese Korean Population
por: Chun, Yoon Hong, et al.
Publicado: (2015)

Elevated plasma levels of the appetite-stimulator ACBP/DBI in fasting and obese subjects
por: Li, Sijing, et al.
Publicado: (2021)

Chronic Reduction of Plasma Free Fatty Acid Improves Mitochondrial Function and Whole-Body Insulin Sensitivity in Obese and Type 2 Diabetic Individuals
por: Daniele, Giuseppe, et al.
Publicado: (2014)

Triglyceride profiling in adipose tissues from obese insulin sensitive, insulin resistant and type 2 diabetes mellitus individuals
por: Al-Sulaiti, Haya, et al.
Publicado: (2018)

Elevated plasma homocysteine in type 2 diabetes mellitus: a risk factor for cardiovascular diseases
por: Ebesunun, Maria Onomhaguan, et al.
Publicado: (2012)

Blood Viscosity in Subjects With Type 2 Diabetes Mellitus: Roles of Hyperglycemia and Elevated Plasma Fibrinogen
por: Sun, Jiehui, et al.
Publicado: (2022)

Metabolic Profiles in Obese Children and Adolescents with Insulin Resistance
por: Kostovski, Marko, et al.
Publicado: (2018)

Decreased Insulin Clearance in Individuals with Elevated 1-h Post-Load Plasma Glucose Levels
por: Marini, Maria Adelaide, et al.
Publicado: (2013)

Elevated Basal Insulin Secretion in Type 2 Diabetes Caused by Reduced Plasma Membrane Cholesterol
por: Nagaraj, Vini, et al.
Publicado: (2016)

Ketone Bodies Are Mildly Elevated in Subjects with Type 2 Diabetes Mellitus and Are Inversely Associated with Insulin Resistance as Measured by the Lipoprotein Insulin Resistance Index
por: Garcia, Erwin, et al.
Publicado: (2020)

Age, Obesity, and Sex Effects on Insulin Sensitivity and Skeletal Muscle Mitochondrial Function
por: Karakelides, Helen, et al.
Publicado: (2010)

Mitochondrial Respiratory Capacity and Content Are Normal in Young Insulin-Resistant Obese Humans
por: Fisher-Wellman, Kelsey H., et al.
Publicado: (2014)

Insulin resistance is associated with epigenetic and genetic regulation of mitochondrial DNA in obese humans
por: Zheng, Louise D., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_9ver0pmjq3p6qa5uaaenpv69lo