A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection

A genome-scale CRISPR knockout library screen of THP-1 human macrophages was performed to identify loss-of-function mutations conferring resistance to Salmonella uptake. The screen identified 183 candidate genes, from which 14 representative genes involved in actin dynamics (ACTR3, ARPC4, CAPZB, TOR...

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Detalles Bibliográficos
Autores principales: Yeung, Amy T. Y., Choi, Yoon Ha, Lee, Amy H. Y., Hale, Christine, Ponstingl, Hannes, Pickard, Derek, Goulding, David, Thomas, Mark, Gill, Erin, Kim, Jong Kyoung, Bradley, Allan, Hancock, Robert E. W., Dougan, Gordon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786873/
https://www.ncbi.nlm.nih.gov/pubmed/31594818
http://dx.doi.org/10.1128/mBio.02169-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786873/
https://www.ncbi.nlm.nih.gov/pubmed/31594818
http://dx.doi.org/10.1128/mBio.02169-19

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