Spermidine/spermine N1-acetyltransferase 1 is a gene-specific transcriptional regulator that drives brain tumor aggressiveness

Spermidine/spermine N1-acetyltransferase 1 (SAT1), the rate limiting enzyme in polyamine catabolism, has broad regulatory roles due to near ubiquitous polyamine binding. We describe a novel function of SAT1 as a gene-specific transcriptional regulator through local polyamine acetylation. SAT1 expres...

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Detalles Bibliográficos
Autores principales: Thakur, Vijay S., Aguila, Brittany, Brett-Morris, Adina, Creighton, Chad J., Welford, Scott M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786946/
https://www.ncbi.nlm.nih.gov/pubmed/31399646
http://dx.doi.org/10.1038/s41388-019-0917-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786946/
https://www.ncbi.nlm.nih.gov/pubmed/31399646
http://dx.doi.org/10.1038/s41388-019-0917-0

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