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Spermidine/spermine N1-acetyltransferase 1 is a gene-specific transcriptional regulator that drives brain tumor aggressiveness

Spermidine/spermine N1-acetyltransferase 1 (SAT1), the rate limiting enzyme in polyamine catabolism, has broad regulatory roles due to near ubiquitous polyamine binding. We describe a novel function of SAT1 as a gene-specific transcriptional regulator through local polyamine acetylation. SAT1 expres...

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Detalles Bibliográficos
Autores principales:	Thakur, Vijay S., Aguila, Brittany, Brett-Morris, Adina, Creighton, Chad J., Welford, Scott M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786946/ https://www.ncbi.nlm.nih.gov/pubmed/31399646 http://dx.doi.org/10.1038/s41388-019-0917-0

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