Cargando…
Differential Clinical Significance of Neurotrophin-3 Expression according to MYCN Amplification and TrkC Expression in Neuroblastoma
BACKGROUND: Neurotrophin-3 (NT-3), a member of the NT family, has only been considered an ancillary compound that provides anti-apoptotic benefits by inactivating tropomyosin receptor kinase C (TrkC)-induced apoptotic signals. However, little is known about the clinical relevance of NT-3 expression...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786962/ https://www.ncbi.nlm.nih.gov/pubmed/31602824 http://dx.doi.org/10.3346/jkms.2019.34.e254 |
_version_ | 1783458156526960640 |
---|---|
author | Seo, Eunseop Kim, Jung-Sun Ma, Young Eun Cho, Hee Won Ju, Hee Young Lee, Soo Hyun Lee, Ji Won Yoo, Keon Hee Sung, Ki Woong Koo, Hong Hoe |
author_facet | Seo, Eunseop Kim, Jung-Sun Ma, Young Eun Cho, Hee Won Ju, Hee Young Lee, Soo Hyun Lee, Ji Won Yoo, Keon Hee Sung, Ki Woong Koo, Hong Hoe |
author_sort | Seo, Eunseop |
collection | PubMed |
description | BACKGROUND: Neurotrophin-3 (NT-3), a member of the NT family, has only been considered an ancillary compound that provides anti-apoptotic benefits by inactivating tropomyosin receptor kinase C (TrkC)-induced apoptotic signals. However, little is known about the clinical relevance of NT-3 expression itself in neuroblastoma. The purpose of this study was to assess NT-3 expression in patients with neuroblastoma and its relevance to clinicopathologic findings and treatment outcomes. METHODS: In this study, expression of NT-3 and TrkC was analyzed using immunohistochemistry in 240 patients with newly diagnosed neuroblastoma. RESULTS: The results of the study revealed that NT-3 expression was associated with older age at diagnosis, localized tumors, and more differentiated tumors but was not associated with early treatment response (degree of residual tumor volume after three cycles of chemotherapy) and progression-free survival (PFS). However, when analysis was confined to patients with MYCN amplified tumors, NT-3 expression was associated with better early treatment response with borderline significance (P = 0.092) and higher PFS (86.9% vs. 58.2%; P = 0.044). In multivariate analysis in patients with MYCN amplified tumors, NT-3 was independent prognostic factor (hazard ratio, 0.246; 95% confidence interval, 0.061–0.997; P = 0.050). In another subgroup analysis, the early treatment response was better if NT-3 was expressed in patients without TrkC expression (P = 0.053) while it was poorer in patients with TrkC expression (P = 0.023). CONCLUSION: This study suggests that NT-3 expression in neuroblastoma has its own clinical significance independent of TrkC expression, and its prognostic significance differs depending on the status of MYCN amplification and/or TrkC expression. |
format | Online Article Text |
id | pubmed-6786962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-67869622019-10-17 Differential Clinical Significance of Neurotrophin-3 Expression according to MYCN Amplification and TrkC Expression in Neuroblastoma Seo, Eunseop Kim, Jung-Sun Ma, Young Eun Cho, Hee Won Ju, Hee Young Lee, Soo Hyun Lee, Ji Won Yoo, Keon Hee Sung, Ki Woong Koo, Hong Hoe J Korean Med Sci Original Article BACKGROUND: Neurotrophin-3 (NT-3), a member of the NT family, has only been considered an ancillary compound that provides anti-apoptotic benefits by inactivating tropomyosin receptor kinase C (TrkC)-induced apoptotic signals. However, little is known about the clinical relevance of NT-3 expression itself in neuroblastoma. The purpose of this study was to assess NT-3 expression in patients with neuroblastoma and its relevance to clinicopathologic findings and treatment outcomes. METHODS: In this study, expression of NT-3 and TrkC was analyzed using immunohistochemistry in 240 patients with newly diagnosed neuroblastoma. RESULTS: The results of the study revealed that NT-3 expression was associated with older age at diagnosis, localized tumors, and more differentiated tumors but was not associated with early treatment response (degree of residual tumor volume after three cycles of chemotherapy) and progression-free survival (PFS). However, when analysis was confined to patients with MYCN amplified tumors, NT-3 expression was associated with better early treatment response with borderline significance (P = 0.092) and higher PFS (86.9% vs. 58.2%; P = 0.044). In multivariate analysis in patients with MYCN amplified tumors, NT-3 was independent prognostic factor (hazard ratio, 0.246; 95% confidence interval, 0.061–0.997; P = 0.050). In another subgroup analysis, the early treatment response was better if NT-3 was expressed in patients without TrkC expression (P = 0.053) while it was poorer in patients with TrkC expression (P = 0.023). CONCLUSION: This study suggests that NT-3 expression in neuroblastoma has its own clinical significance independent of TrkC expression, and its prognostic significance differs depending on the status of MYCN amplification and/or TrkC expression. The Korean Academy of Medical Sciences 2019-09-18 /pmc/articles/PMC6786962/ /pubmed/31602824 http://dx.doi.org/10.3346/jkms.2019.34.e254 Text en © 2019 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Seo, Eunseop Kim, Jung-Sun Ma, Young Eun Cho, Hee Won Ju, Hee Young Lee, Soo Hyun Lee, Ji Won Yoo, Keon Hee Sung, Ki Woong Koo, Hong Hoe Differential Clinical Significance of Neurotrophin-3 Expression according to MYCN Amplification and TrkC Expression in Neuroblastoma |
title | Differential Clinical Significance of Neurotrophin-3 Expression according to MYCN Amplification and TrkC Expression in Neuroblastoma |
title_full | Differential Clinical Significance of Neurotrophin-3 Expression according to MYCN Amplification and TrkC Expression in Neuroblastoma |
title_fullStr | Differential Clinical Significance of Neurotrophin-3 Expression according to MYCN Amplification and TrkC Expression in Neuroblastoma |
title_full_unstemmed | Differential Clinical Significance of Neurotrophin-3 Expression according to MYCN Amplification and TrkC Expression in Neuroblastoma |
title_short | Differential Clinical Significance of Neurotrophin-3 Expression according to MYCN Amplification and TrkC Expression in Neuroblastoma |
title_sort | differential clinical significance of neurotrophin-3 expression according to mycn amplification and trkc expression in neuroblastoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786962/ https://www.ncbi.nlm.nih.gov/pubmed/31602824 http://dx.doi.org/10.3346/jkms.2019.34.e254 |
work_keys_str_mv | AT seoeunseop differentialclinicalsignificanceofneurotrophin3expressionaccordingtomycnamplificationandtrkcexpressioninneuroblastoma AT kimjungsun differentialclinicalsignificanceofneurotrophin3expressionaccordingtomycnamplificationandtrkcexpressioninneuroblastoma AT mayoungeun differentialclinicalsignificanceofneurotrophin3expressionaccordingtomycnamplificationandtrkcexpressioninneuroblastoma AT choheewon differentialclinicalsignificanceofneurotrophin3expressionaccordingtomycnamplificationandtrkcexpressioninneuroblastoma AT juheeyoung differentialclinicalsignificanceofneurotrophin3expressionaccordingtomycnamplificationandtrkcexpressioninneuroblastoma AT leesoohyun differentialclinicalsignificanceofneurotrophin3expressionaccordingtomycnamplificationandtrkcexpressioninneuroblastoma AT leejiwon differentialclinicalsignificanceofneurotrophin3expressionaccordingtomycnamplificationandtrkcexpressioninneuroblastoma AT yookeonhee differentialclinicalsignificanceofneurotrophin3expressionaccordingtomycnamplificationandtrkcexpressioninneuroblastoma AT sungkiwoong differentialclinicalsignificanceofneurotrophin3expressionaccordingtomycnamplificationandtrkcexpressioninneuroblastoma AT koohonghoe differentialclinicalsignificanceofneurotrophin3expressionaccordingtomycnamplificationandtrkcexpressioninneuroblastoma |