Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets

Lipid availability within transmembrane nano-pockets of ion channels is linked with mechanosensation. However, the effect of hindering lipid-chain penetration into nano-pockets on channel structure has not been demonstrated. Here we identify nano-pockets on the large conductance mechanosensitive cha...

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Detalles Bibliográficos
Autores principales: Kapsalis, Charalampos, Wang, Bolin, El Mkami, Hassane, Pitt, Samantha J., Schnell, Jason R., Smith, Terry K., Lippiat, Jonathan D., Bode, Bela E., Pliotas, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787021/
https://www.ncbi.nlm.nih.gov/pubmed/31601809
http://dx.doi.org/10.1038/s41467-019-12591-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787021/
https://www.ncbi.nlm.nih.gov/pubmed/31601809
http://dx.doi.org/10.1038/s41467-019-12591-x

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