Cargando…

Ubiquitin receptors are required for substrate-mediated activation of the proteasome’s unfolding ability

The ubiquitin-proteasome system (UPS) is responsible for the bulk of protein degradation in eukaryotic cells, but the factors that cause different substrates to be unfolded and degraded to different extents are still poorly understood. We previously showed that polyubiquitinated substrates were degr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cundiff, Mary D., Hurley, Christina M., Wong, Jeremy D., Boscia, Joseph A., Bashyal, Aarti, Rosenberg, Jake, Reichard, Eden L., Nassif, Nicholas D., Brodbelt, Jennifer S., Kraut, Daniel A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787058/ https://www.ncbi.nlm.nih.gov/pubmed/31601863 http://dx.doi.org/10.1038/s41598-019-50857-y

Ejemplares similares

The 26S Proteasome Switches between ATP-Dependent and -Independent Mechanisms in Response to Substrate Ubiquitination
por: Manfredonia, Abramo J., et al.
Publicado: (2022)

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates
por: Korolchuk, Viktor I., et al.
Publicado: (2009)

Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates
por: Trulsson, Fredrik, et al.
Publicado: (2022)

Immuno- and Constitutive Proteasomes Do Not Differ in Their Abilities to Degrade Ubiquitinated Proteins
por: Nathan, James A., et al.
Publicado: (2013)

USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites
por: Lee, Byung-Hoon, et al.
Publicado: (2016)

Ubiquitin modulates 26S proteasome conformational dynamics and promotes substrate degradation
por: Jonsson, Erik, et al.
Publicado: (2022)

Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase
por: Kong, Ka-Yiu Edwin, et al.
Publicado: (2021)

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation
por: Lindsten, Kristina, et al.
Publicado: (2002)

Autoregulation of the 26S proteasome by in situ ubiquitination
por: Jacobson, Andrew D., et al.
Publicado: (2014)

VWA domain of S5a restricts the ability to bind ubiquitin and Ubl to the 26S proteasome
por: Piterman, Ravit, et al.
Publicado: (2014)

Bacterial Effectors and Their Functions in the Ubiquitin-Proteasome System: Insight from the Modes of Substrate Recognition
por: Kim, Minsoo, et al.
Publicado: (2014)

Variation in ubiquitin system genes creates substrate-specific effects on proteasomal protein degradation
por: Collins, Mahlon A, et al.
Publicado: (2022)

Enzymatic Blockade of the Ubiquitin-Proteasome Pathway
por: Ernst, Robert, et al.
Publicado: (2011)

Adaptability of the ubiquitin-proteasome system to proteolytic and folding stressors
por: Work, Jeremy J., et al.
Publicado: (2020)

The ubiquitin-proteasome pathway in cancer.
por: Spataro, V., et al.
Publicado: (1998)

The ubiquitin proteasome system in neuropathology
por: Lehman, Norman L.
Publicado: (2009)

The recognition of ubiquitinated proteins by the proteasome
por: Grice, Guinevere L., et al.
Publicado: (2016)

The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates
por: Martinez-Fonts, Kirby, et al.
Publicado: (2020)

The Ubiquitin Proteasome System in Ischemic and Dilated Cardiomyopathy
por: Spänig, Sabine, et al.
Publicado: (2019)

Proteasome in action: substrate degradation by the 26S proteasome
por: Sahu, Indrajit, et al.
Publicado: (2021)

Regulation of TRAIL-Receptor Expression by the Ubiquitin-Proteasome System
por: Sarhan, Dhifaf, et al.
Publicado: (2014)

The ubiquitin-proteasome system is required for African swine fever replication
por: Barrado-Gil, Lucía, et al.
Publicado: (2017)

The Ubiquitin Conjugating Enzyme: An Important Ubiquitin Transfer Platform in Ubiquitin-Proteasome System
por: Liu, Weigang, et al.
Publicado: (2020)

Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation
por: Wang, Tao, et al.
Publicado: (2010)

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies
por: Longva, Karianne E., et al.
Publicado: (2002)

Poxvirus Exploitation of the Ubiquitin-Proteasome System
por: Barry, Michele, et al.
Publicado: (2010)

The Ubiquitin-Proteasome Pathway in Huntington's Disease
por: Mitra, Siddhartha, et al.
Publicado: (2008)

The ubiquitin-proteasome system in Alzheimer's disease
por: Oddo, Salvatore
Publicado: (2008)

Ubiquitin Proteasome System in Stress and Disease
por: Karpov, Dmitry, et al.
Publicado: (2012)

Intracellular Dynamics of the Ubiquitin-Proteasome-System
por: Chowdhury, Maisha, et al.
Publicado: (2015)

Ubiquitin-Proteasome System in Neurodegenerative Disorders
por: Rao, Geeta, et al.
Publicado: (2015)

The Ubiquitin–Proteasome System in Immune Cells
por: Çetin, Gonca, et al.
Publicado: (2021)

Ubiquitin-proteasome system in diabetic retinopathy
por: Svikle, Zane, et al.
Publicado: (2022)

Copper homeostasis and the ubiquitin proteasome system
por: Zhang, Bichao, et al.
Publicado: (2023)

The Ubiquitin–Proteasome System in Tumor Metabolism
por: Wang, Jie, et al.
Publicado: (2023)

The Ubiquitin-associated (UBA) 1 Domain of Schizosaccharomyces pombe Rhp23 Is Essential for the Recognition of Ubiquitin-proteasome System Substrates Both in Vitro and in Vivo
por: Medina, Bethan, et al.
Publicado: (2012)

Ubiquitin Proteasome System Role in Diabetes-Induced Cardiomyopathy
por: Nahum-Ankonina, Ortal, et al.
Publicado: (2023)

Requirement of dendritic Akt degradation by the ubiquitin–proteasome system for neuronal polarity
por: Yan, Dong, et al.
Publicado: (2006)

KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence
por: Álvarez, Alhejandra, et al.
Publicado: (2017)

Ubiquitin–Proteasome System Is Required for Efficient Replication of Singapore Grouper Iridovirus
por: Huang, Xiaohong, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_t5brve7g16u0gq6pncte04q5eg