DNA sequence-dependent chromatin architecture and nuclear hubs formation

In this study, by exploring chromatin conformation capture data, we show that the nuclear segregation of Topologically Associated Domains (TADs) is contributed by DNA sequence composition. GC-peaks and valleys of TADs strongly influence interchromosomal interactions and chromatin 3D structure. To ga...

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Detalles Bibliográficos
Autores principales: Jabbari, Kamel, Chakraborty, Maharshi, Wiehe, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787200/
https://www.ncbi.nlm.nih.gov/pubmed/31601866
http://dx.doi.org/10.1038/s41598-019-51036-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787200/
https://www.ncbi.nlm.nih.gov/pubmed/31601866
http://dx.doi.org/10.1038/s41598-019-51036-9

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