Low human and murine Mcl-1 expression leads to a pro-apoptotic plaque phenotype enriched in giant-cells

The anti-apoptotic protein myeloid cell leukemia 1 (Mcl-1) plays an important role in survival and differentiation of leukocytes, more specifically of neutrophils. Here, we investigated the impact of myeloid Mcl-1 deletion in atherosclerosis. Western type diet fed LDL receptor-deficient mice were tr...

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Detalles Bibliográficos
Autores principales: Fontaine, Margaux A. C., Westra, Marijke M., Bot, Ilze, Jin, Han, Franssen, Aimée J. P. M., Bot, Martine, de Jager, Saskia C. A., Dzhagalov, Ivan, He, You-Wen, van Vlijmen, Bart J. M., Gijbels, Marion J. J., Reutelingsperger, Chris P., van Berkel, Theo J. C., Sluimer, Judith C., Temmerman, Lieve, Biessen, Erik A. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787218/
https://www.ncbi.nlm.nih.gov/pubmed/31601924
http://dx.doi.org/10.1038/s41598-019-51020-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787218/
https://www.ncbi.nlm.nih.gov/pubmed/31601924
http://dx.doi.org/10.1038/s41598-019-51020-3

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