Cargando…

Crystal structure of ErmE - 23S rRNA methyltransferase in macrolide resistance

Pathogens often receive antibiotic resistance genes through horizontal gene transfer from bacteria that produce natural antibiotics. ErmE is a methyltransferase (MTase) from Saccharopolyspora erythraea that dimethylates A2058 in 23S rRNA using S-adenosyl methionine (SAM) as methyl donor, protecting...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stsiapanava, Alena, Selmer, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787224/ https://www.ncbi.nlm.nih.gov/pubmed/31601908 http://dx.doi.org/10.1038/s41598-019-51174-0

Ejemplares similares

Critical 23S rRNA interactions for macrolide-dependent ribosome stalling on the ErmCL nascent peptide chain
por: Koch, Miriam, et al.
Publicado: (2017)

Crystal structure of RlmM, the 2′O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
por: Punekar, Avinash S., et al.
Publicado: (2012)

Three critical regions of the erythromycin resistance methyltransferase, ErmE, are required for function supporting a model for the interaction of Erm family enzymes with substrate rRNA
por: Sharkey, Rory E., et al.
Publicado: (2022)

Purification, crystallization and preliminary X-ray diffraction analysis of the 23S rRNA methyltransferase RlmJ from Escherichia coli
por: Punekar, Avinash S., et al.
Publicado: (2013)

Macrolide Resistance–associated 23S rRNA Mutation in Mycoplasma genitalium, Japan
por: Shimada, Yasushi, et al.
Publicado: (2011)

Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance.
por: Svetlov, Maxim S., et al.
Publicado: (2021)

erm(T)-Mediated Macrolide-Lincosamide Resistance in Streptococcus suis
por: Yu, Rui, et al.
Publicado: (2022)

Mutation at the position 2058 of the 23S rRNA as a cause of macrolide resistance in Streptococcus pyogenes
por: Jalava, Jari, et al.
Publicado: (2004)

Direct assessment of possible mutations in the 23S rRNA gene encoding macrolide resistance in Chlamydia trachomatis
por: van Niekerk, J. M., et al.
Publicado: (2022)

Crystal structure and functional analysis of mycobacterial erythromycin resistance methyltransferase Erm38 reveals its RNA-binding site
por: Goh, Boon Chong, et al.
Publicado: (2022)

Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ
por: Punekar, Avinash S., et al.
Publicado: (2013)

Detection of macrolide resistance genes, ermC and ermB, in Japanese honey using real-time PCR assays
por: OKAMOTO, Mariko, et al.
Publicado: (2022)

Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A
por: Chen, Chih-Wei, et al.
Publicado: (2023)

Increases in the Macrolide Resistance of Mycoplasma genitalium and the Emergence of the A2058T Mutation in the 23S rRNA Gene: Clonal Spread?
por: Piñeiro, Luis, et al.
Publicado: (2022)

Inducible Expression of both ermB and ermT Conferred High Macrolide Resistance in Streptococcus gallolyticus subsp. pasteurianus Isolates in China
por: Li, Meixia, et al.
Publicado: (2016)

Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria
por: Kaminska, Katarzyna H., et al.
Publicado: (2010)

Cigarette smoke exposure induces expression of the pneumococcal erm(B) macrolide resistance gene
por: Matapa, Kgashane Given, et al.
Publicado: (2019)

Novel macrolide-lincosamide-streptogramin B resistance gene erm(56) in Trueperella pyogenes
por: Marchionatti, Emma, et al.
Publicado: (2023)

Detection of macrolide and fluoroquinolone resistance-associated 23S rRNA and parC mutations in Mycoplasma genitalium by nested real-time PCR
por: He, Wenyin, et al.
Publicado: (2023)

Regulation of the erm(C) Gene in Staphylococci from Reservoir with Different Usage of Macrolides
por: Jensen, Lars B, et al.
Publicado: (2005)

Identification of allosteric hotspots regulating the ribosomal RNA binding by antibiotic resistance-conferring Erm methyltransferases
por: Bhujbalrao, Ruchika, et al.
Publicado: (2022)

Time-to-Detection of Inducible Macrolide Resistance in Mycobacterium abscessus Subspecies and Its Association with the Erm(41) Sequevar
por: Christianson, Sara, et al.
Publicado: (2016)

A Novel SimpleProbe PCR Assay for Detection of Mutations in the 23S rRNA Gene Associated with Macrolide Resistance in Mycoplasma genitalium in Clinical Samples
por: Gossé, Marianne, et al.
Publicado: (2016)

A mitochondrial rRNA dimethyladenosine methyltransferase in Arabidopsis
por: Richter, Uwe, et al.
Publicado: (2010)

Research Updates of Plasmid-Mediated Aminoglycoside Resistance 16S rRNA Methyltransferase
por: Yang, Weiwei, et al.
Publicado: (2022)

Heterogeneity of macrolide-lincosamide-streptogramin phenotype & conjugal transfer of erm(B) in Pediococcus pentosaceus
por: Thumu, Surya Chandra Rao, et al.
Publicado: (2019)

16-membered ring macrolides and erythromycin induce ermB expression by different mechanisms
por: He, Weizhi, et al.
Publicado: (2022)

Overexpression of 18S rRNA methyltransferase CrBUD23 enhances biomass and lutein content in Chlamydomonas reinhardtii
por: Liu, Chenglong, et al.
Publicado: (2023)

Structural Insights into the Methylation of C1402 in 16S rRNA by Methyltransferase RsmI
por: Zhao, Mohan, et al.
Publicado: (2016)

Structural basis for the specific recognition of 18S rRNA by APUM23
por: Bao, Hongyu, et al.
Publicado: (2017)

Point Deletion or Insertion in CmeR-Box, A2075G Substitution in 23S rRNA, and Presence of erm(B) Are Key Factors of Erythromycin Resistance in Campylobacter jejuni and Campylobacter coli Isolated From Central China
por: Cheng, Yiluo, et al.
Publicado: (2020)

A long-distance rRNA base pair impacts the ability of macrolide antibiotics to kill bacteria
por: Svetlov, Maxim S., et al.
Publicado: (2020)

Mutations in the 23S rRNA gene of Helicobacter pylori associated with clarithromycin resistance.
por: Kim, Kyung Suk, et al.
Publicado: (2002)

Analysis of the function of E. coli 23S rRNA helix-loop 69 by mutagenesis
por: Liiv, Aivar, et al.
Publicado: (2005)

Staphylococcus aureus with an erm-mediated constitutive macrolide-lincosamide-streptogramin B resistance phenotype has reduced susceptibility to the new ketolide, solithromycin
por: Yao, Weiming, et al.
Publicado: (2019)

16S rRNA Methyltransferase RmtC in Salmonella enterica Serovar Virchow
por: Hopkins, Katie L., et al.
Publicado: (2010)

Modification of Adenosine196 by Mettl3 Methyltransferase in the 5’-External Transcribed Spacer of 47S Pre-rRNA Affects rRNA Maturation
por: Sergeeva, Olga, et al.
Publicado: (2020)

Course of Lower Respiratory Tract Infection in Young People Treated at the Military Hospital of Smolensk Garrison with Detected Mycoplasma pneumoniae Carrying a Macrolide-Resistant Mutation in 23S rRNA Gene
por: Edelstein, Inna Alexandrovna, et al.
Publicado: (2023)

Binding of aminoglycoside antibiotics to helix 69 of 23S rRNA
por: Scheunemann, Ann E., et al.
Publicado: (2010)

The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis
por: Zorbas, Christiane, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_lt9tkt7nb9mmde3dupv5irmm8r