Cargando…

Oligomeric state of the ZIKV E protein defines protective immune responses

The current leading Zika vaccine candidates in clinical testing are based on live or killed virus platforms, which have safety issues, especially in pregnant women. Zika subunit vaccines, however, have shown poor performance in preclinical studies, most likely because the antigens tested do not disp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Metz, Stefan W., Thomas, Ashlie, Brackbill, Alex, Forsberg, John, Miley, Michael J., Lopez, Cesar A., Lazear, Helen M., Tian, Shaomin, de Silva, Aravinda M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787251/ https://www.ncbi.nlm.nih.gov/pubmed/31601808 http://dx.doi.org/10.1038/s41467-019-12677-6

Ejemplares similares

Nanoparticle delivery of a tetravalent E protein subunit vaccine induces balanced, type-specific neutralizing antibodies to each dengue virus serotype
por: Metz, Stefan W., et al.
Publicado: (2018)

In Vitro Assembly and Stabilization of Dengue and Zika Virus Envelope Protein Homo-Dimers
por: Metz, Stefan W., et al.
Publicado: (2017)

Precisely Molded Nanoparticle Displaying DENV-E Proteins Induces Robust Serotype-Specific Neutralizing Antibody Responses
por: Metz, Stefan W., et al.
Publicado: (2016)

Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil
por: Calvet, Guilherme Amaral, et al.
Publicado: (2018)

Identification of Inhibitors of ZIKV Replication
por: Morales Vasquez, Desarey, et al.
Publicado: (2020)

Coinfection with Zika Virus (ZIKV) and Dengue Virus Results in Preferential ZIKV Transmission by Vector Bite to Vertebrate Host
por: Chaves, Barbara Aparecida, et al.
Publicado: (2018)

Antiviral effects of the fused tricyclic derivatives of indoline and imidazolidinone on ZIKV infection and RdRp activities of ZIKV and DENV
por: Zhou, Guang-Feng, et al.
Publicado: (2023)

ZIKV Strains Differentially Affect Survival of Human Fetal Astrocytes versus Neurons and Traffic of ZIKV-Laden Endocytotic Compartments
por: Jorgačevski, Jernej, et al.
Publicado: (2019)

Maternal Zika Virus (ZIKV) Infection following Vaginal Inoculation with ZIKV-Infected Semen in Timed-Pregnant Olive Baboons
por: Gurung, Sunam, et al.
Publicado: (2020)

Ribavirin inhibits Zika virus (ZIKV) replication in vitro and suppresses viremia in ZIKV-infected STAT1-deficient mice
por: Kamiyama, Naganori, et al.
Publicado: (2017)

Dengue virus-like particles mimic the antigenic properties of the infectious dengue virus envelope
por: Metz, Stefan W., et al.
Publicado: (2018)

Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections
por: Wales-McGrath, Benjamin, et al.
Publicado: (2023)

Boroleucine‐Derived Covalent Inhibitors of the ZIKV Protease
por: Braun, Niklas J., et al.
Publicado: (2022)

Adenoviral vector type 26 encoding Zika virus (ZIKV) M-Env antigen induces humoral and cellular immune responses and protects mice and nonhuman primates against ZIKV challenge
por: Cox, Freek, et al.
Publicado: (2018)

ZIKV induction of tristetraprolin in endothelial and Sertoli cells post-transcriptionally inhibits IFNβ/λ expression and promotes ZIKV persistence
por: Schutt, William R., et al.
Publicado: (2023)

Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection
por: Collins, Matthew H., et al.
Publicado: (2017)

Protection of ZIKV infection-induced neuropathy by abrogation of acute antiviral response in human neural progenitors
por: Liu, Ling, et al.
Publicado: (2019)

Variation in competence for ZIKV transmission by Aedes aegypti and Aedes albopictus in Mexico
por: Garcia-Luna, Selene M., et al.
Publicado: (2018)

Analysis of methyltransferase (MTase) domain from Zika virus (ZIKV)
por: Afaq, Sarah, et al.
Publicado: (2020)

ZIKV infection regulates inflammasomes pathway for replication in monocytes
por: Khaiboullina, S. F., et al.
Publicado: (2017)

History of ZIKV Infections in India and Management of Disease Outbreaks
por: Khaiboullina, Svetalana, et al.
Publicado: (2018)

Sertoli Cells Are Susceptible to ZIKV Infection in Mouse Testis
por: Sheng, Zi-Yang, et al.
Publicado: (2017)

ZIKV viral proteins and their roles in virus-host interactions
por: Guo, Moujian, et al.
Publicado: (2020)

Virus Cooperation, ZIKV Viremia and in Utero Fetus Infection
por: Goldschmidt-Clermont, Pascal J., et al.
Publicado: (2019)

AXL, an Important Host Factor for DENV and ZIKV Replication
por: Xie, Shengda, et al.
Publicado: (2021)

Phenotypic and Genetic Variability of Isolates of ZIKV-2016 in Brazil
por: Raphael, Lidiane Menezes Souza, et al.
Publicado: (2022)

Host immune response against DENV and ZIKV infections
por: Sekaran, Shamala Devi, et al.
Publicado: (2022)

Increased growth ability and pathogenicity of American- and Pacific-subtype Zika virus (ZIKV) strains compared with a Southeast Asian-subtype ZIKV strain
por: Kawai, Yasuhiro, et al.
Publicado: (2019)

The Potential Role of the ZIKV NS5 Nuclear Spherical-Shell Structures in Cell Type-Specific Host Immune Modulation during ZIKV Infection
por: Tan, Min Jie Alvin, et al.
Publicado: (2019)

One-step RT-qPCR assay for ZIKV RNA detection in Aedes aegypti samples: a protocol to study infection and gene expression during ZIKV infection
por: Araujo, Ricardo Vieira, et al.
Publicado: (2020)

Persistence of Anti-ZIKV-IgG over Time Is Not a Useful Congenital Infection Marker in Infants Born to ZIKV-Infected Mothers: The NATZIG Cohort
por: Coutinho, Conrado Milani, et al.
Publicado: (2021)

Interferon Lambda Signals in Maternal Tissues to Exert Protective and Pathogenic Effects in a Gestational Stage-Dependent Manner
por: Casazza, Rebecca L., et al.
Publicado: (2022)

ZIKV can infect human term placentas in the absence of maternal factors
por: Villazana-Kretzer, Diana L., et al.
Publicado: (2022)

Revealing the characteristics of ZIKV infection through tissue-specific transcriptome sequencing analysis
por: Chen, Zhi-lu, et al.
Publicado: (2022)

Overview of Zika virus (ZIKV) infection in regards to the Brazilian epidemic
por: Slavov, S.N., et al.
Publicado: (2016)

Comparative Normal Mode Analysis of the Dynamics of DENV and ZIKV Capsids
por: Hsieh, Yin-Chen, et al.
Publicado: (2016)

ZIKV Envelope Domain-Specific Antibodies: Production, Purification and Characterization
por: Akhras, Sami, et al.
Publicado: (2019)

The Molecular Interactions of ZIKV and DENV with the Type-I IFN Response
por: Coldbeck-Shackley, Rosa C., et al.
Publicado: (2020)

Chloroquine and Sulfadoxine Derivatives Inhibit ZIKV Replication in Cervical Cells
por: de Souza, Audrien Alves Andrade, et al.
Publicado: (2020)

Neurodevelopment in the third year of life in children with antenatal ZIKV-exposure
por: Aizawa, Carolina Yuri Panvequio, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cr7r8imo81ka5lvm3if3qnlge9