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Ca(2+)-dependent recruitment of voltage-gated sodium channels underlies bilirubin-induced overexcitation and neurotoxicity

Neonatal jaundice is prevalent among newborns and can lead to severe neurological deficits, particularly sensorimotor dysfunction. Previous studies have shown that bilirubin (BIL) enhances the intrinsic excitability of central neurons and this can potentially contribute to their overexcitation, Ca(2...

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Detalles Bibliográficos
Autores principales: Shi, Hao-Song, Lai, Ke, Yin, Xin-Lu, Liang, Min, Ye, Hai-Bo, Shi, Hai-Bo, Wang, Lu-Yang, Yin, Shan-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787254/
https://www.ncbi.nlm.nih.gov/pubmed/31601780
http://dx.doi.org/10.1038/s41419-019-1979-1